Packaging
Packaging
Development of polymer monolith-MOF hybrid via surface functionalization for bioanalytical sciences
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Monoliths are versatile materials with diverse applications, and their performance can be enhanced through modifications, including the use of metal–organic frameworks (MOFs). Modified monoliths...
Inhibition of ATP Citrate Lyase by Hydroxycitrate-Loaded Exosomes Suppresses the Survival of Lung Adenocarcinoma Cells
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Abstract The metabolic enzyme ATP citrate lyase is overexpressed in several cancers and links glucose metabolism with de novo fatty acid synthesis pathway by catalyzing the...
The Molecular Mechanism of Resveratrol in the Treatment of Chronic Rhinosinusitis Through a Combination of Network Pharmacology and In Vitro Validation
25/02/2025 -
A combination of network pharmacology and in vitro validation was used to reveal the potential targets and molecular mechanisms of resveratrol for CRS treatment.ABSTRACTResveratrol (RES) is a...
New Benzothiazole‐Thiadiazole‐Based Ketones as Potential Antiviral and Anticancer Agents: Synthesis, DFT, and Molecular Docking Studies
23/02/2025 -
ABSTRACTVarious substituted benzothiazole‐thiadiazole‐based ketones 4a‐i and 6a‐c were synthesized and characterized by the IR, NMR, and MS spectral data. The DFT study of the synthesized...
Unravelling the Antibiotic Resistance: Molecular Insights and Combating Therapies
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Abstract Antibiotics, the full-stop of invasive bacteria, have been used in clinical setups from unthreatening fever to massive challenging therapies. Constant dependency on...
99mTc‐HYNIC PEGylated Peptide Probe Targeting HER2‐Expression in Breast Cancer
19/02/2025 -
Introduction of PEG12 chain had a positive influence also on the pharmacokinetics demonstrating significantly improved tumour activity and target‐to‐non‐target ratios proving...
Advanced Drug Delivery Systems Utilizing β‐Lactoglobulin: An Efficient Protein‐Based Drug Carrier
06/02/2025 -
β‐Lactoglobulin (BLG) is a chief component of whey protein having unique functional properties for drug delivery. This review discusses the utilization of BLG in several drug delivery systems as a...
Analyzing Oxygen Atom Distribution in FDA‐Approved Drugs to Enhance Drug Discovery Strategies
06/02/2025 -
Analysis of prevalence of ring, nonring, sp3‐, and sp2‐hybridized oxygen in approved drugs. For the first time, analysis of distribution of different types of oxygen from center of mass of a...
An Update of Fungal Endophyte Diversity and Strategies for Augmenting Therapeutic Potential of their Potent Metabolites: Recent Advancement
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Abstract Endophytic fungi represent a significant renewable resource for the discovery of pharmaceutically important compounds, offering substantial potential for new drug...
Using Network Pharmacology and Transcriptome Sequencing to Investigate the Mechanism of Action of Luteolin and Quercetin in Treating Obesity
05/02/2025 -
This study elucidated the mechanisms by which luteolin and quercetin treat obesity using network pharmacology and transcriptome sequencing, and validated the pertinent targets and pathways involved...
Requirements for fast multianalyte detection and characterisation via electrochemical-assisted SERS in a reusable and easily manufactured flow cell
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Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive analytical technique that captures vibrational spectra of analytes adsorbed to rough coin metal surfaces with remarkable signal...
Bioactive Functionalized Chitosan Thermo‐Responsive Hydrogels as Promising Platforms for Therapeutic, Regenerative Oral, and Maxillofacial Applications
25/01/2025 -
Graphical Abstract and Lay SummaryBecause of their superior physicochemical qualities, chitosan thermosensitive hydrogels are a multipurpose platform that is frequently used in the biomedical...
Adenocarpine, Marmesin, and Lycocernuine from Ficus benjamina as Promising Inhibitors of Aldose Reductase in Diabetes: A Bioinformatics-Guided Approach
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Abstract Diabetes affects approximately 422 million people worldwide, leading to 1.5 million deaths annually and causing severe complications such as kidney failure, neuropathy,...
Heterologous Biosynthesis of Terpenoids in Saccharomyces cerevisiae
20/01/2025 -
Graphical Abstract and Lay SummaryTerpenoids are widely distributed in nature and have various applications in healthcare products, pharmaceuticals, and fragrances. This article primarily centers on...
The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies
22/01/2025 -
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual...
Artificial Neural NetworkâBased Validation, DFT, Thermal and Biological Evaluation of 4-Aminoantipyrine-Derived Ru(III) Complexes
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Abstract New methodologies have been evaluated for validating analytical characterization with artificial neural networks (ANNs). Compared to previous machine learning models,...
Triune Engineering Approach for (+)‐valencene Overproduction in Yarrowia lipolytica
16/01/2025 -
Graphical Abstract and Lay SummaryThe sesquiterpene (+)‐valencene, with its flavor and diverse biological functions, holds promise for applications in the food, fragrance, and pharmaceutical...
Prediction of Multi-targeting Pharmacological Activity of Bioactive Compounds from Medicinal Plants Against Hepatocellular Carcinoma Through Advanced Network Pharmacology and Bioinformatics-Based Investigation
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Abstract The primary objective of this study was to identify bioactive compounds from four medicinal plants with multi-targeting activity against hepatocellular carcinoma (HCC). A...
Machine Learning‐Assisted High‐Throughput Screening of Nanozymes for Ulcerative Colitis
12/01/2025 -
A data‐driven design strategy is developed for UC therapeutic nanozymes. The optimal CT‐imageable oral UC therapeutic nanozyme SrDy2O4 is successfully discovered and the high‐dimensional...
Integrating LCâMS/MS and In Silico Methods to Uncover Bioactive Compounds with Lipase Inhibitory Potential in the Antarctic Moss Warnstorfia fontinaliopsis
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Abstract Antarctic organisms are known for producing unique secondary metabolites, and this study specifically focuses on the less-explored metabolites of the moss Warnstorfia...
In Vitro Cytotoxic Potential and Integrated Network Pharmacology, Molecular Docking and Molecular Dynamic Approaches to Decipher the Mechanism of Gymnostachyum febrifugum Benth., in the Treatment of Breast Cancer
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Abstract Gymnostachyum febrifugum, a less-known ethnomedicinal plant from the Western Ghats of India, is used to treat various diseases and serves as an antioxidant and...
