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Chemical composition of extracts and fractions from Miconia ibaguensis (MELASTOMATACEAE) leaves and evaluation of biological activities
15/05/2024 -
The study aimed to assess the chemical composition of Miconia ibaguensis leaves extracts and fractions obtained from the ethanolic extract (EE), along with evaluating their antifungal, antibacterial,...
Plant-derived bioactive compounds for the inhibition of biofilm formation: a comprehensive review
15/05/2024 -
Biofilm formation is a widespread phenomenon that impacts different fields, including the food industry, agriculture, health care and the environment. Accordingly, there is a serious need for new...
Sono-assisted photocatalytic degradation of ciprofloxacin in aquatic media using g-C3N4/MOF-based nanocomposite under visible light irradiation
14/05/2024 -
This research study is centered on the sono-assisted photocatalytic degradation of a well-known antibiotic (ciprofloxacin; CIP) in aquatic media using a g-C3N4/NH2-UiO-66 (Zr) catalyst under...
Synthesis, Biological and Molecular Docking Studies of Thiazole?Thiadiazole derivatives as potential Anti?Tuberculosis Agents
12/05/2024 -
Tuberculosis remains a global health threat, with increasing infection rates and mortality despite existing anti?TB drugs. The present work focuses on the research findings regarding the development...
Asymmetric Carbene Transfer: Enhancing Chemical Diversity for Drug Discovery
12/05/2024 -
The exploration of chemical space for disease targets is of paramount importance. However, the current repertoire of chemically synthesized compounds, numbering around 108, merely scratches the...
Modeling and optimization of triclosan biodegradation by the newly isolated Bacillus sp. DL4: kinetics and pathway speculation
11/05/2024 -
Triclosan is a widely used antibacterial agent and disinfectant, and its overuse endangered ecological safety and human health. Therefore, reducing residual TCS concentrations in the environment...
Microplastics in the environment: analytical chemistry methods, sorption materials, risks and sustainable solutions
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This Feature Article reports general and more specific aspects about microplastic (MP) contamination in continental and marine waters as well as in terrestrial environment. It describes a critical...
Developmental Formulation Principles of Food Preservatives by Nanoencapsulationâ??Fundamentals, Application, and Challenges
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Abstract The role of food additives is to preserve food by extending shelf life and limiting harmful microorganism proliferation. They prevent spoilage by enhancing the taste and...
Gluconic Acid Production by Using Recombinant Escherichia coli Waksman pqq+ Cells with a Novel Approach from Biomass Sources
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Abstract Gluconic acid (GA) is widely used in the pharmaceutical, food, detergent, textile, leather, and concrete industries. However, cost-effective and high-yield production of...
Synthesis of (Hetero)biaryls via Nickel Catalyzed Reductive Cross?Electrophile Coupling Between (Hetero)aryl Iodides and Bromides
09/05/2024 -
(Hetero)biaryls are fundamental building blocks in the pharmaceutical industry and rapid access to these scaffolds is imperative for the success of numerous medicinal chemistry campaigns. Herein, a...
Novel Pyrazole?Chalcone Hybrids: Synthesis and Computational Insights Against Breast Cancer.
05/05/2024 -
More women die of breast cancer than of any other malignancy. The resistance and toxicity of traditional hormone therapy created an urgent need for potential molecules for treating breast cancer...
Dinuclear Rhenium(I) Tricarbonyl Complexes as Anticancer Drug Candidates
03/05/2024 -
In this study the chemical synthesis and biological evaluation of dinuclear rhenium(I) complexes as potential chemotherapeutic drug candidates are presented. The metal complexes primarily accumulated...
Synthesis of Indolines via Base?Mediated C–H Activation and Defluorinative C–N Coupling, with no Need for Transition?Metals
01/05/2024 -
Syntheses of (partially) aromatic nitrogen heterocycles increasingly rely on transition?metal catalyzed C–C? and C–N?cross?coupling reactions. Here we describe a different approach to the...
Occurrence of pharmaceutically active compounds in groundwater and their effects to the human health
01/05/2024 -
Groundwater contamination by pharmaceutically active compounds (PhACs) has been considered a public health concern worldwide. Alongside the potential toxicological risk of these organic...
Pharmacological Mechanism of Mume Fructus in the Treatment of Triple-Negative Breast Cancer Based on Network Pharmacology
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Abstract Our study aims to find the relevant mechanism of Mume Fructus in the treatment of triple-negative breast cancer (TNBC) by network pharmacology analysis and experimental...
Application of Goat and Lamb Lipases on the Development of New Immobilized Biocatalysts Aiming at Fish Oil Hydrolysis
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Abstract The use of lipases from animal sources for the synthesis of new biocatalysts is barely studied in the literature. The present work focused on the immobilization of...
Optimization and validation of multiresidual extraction methods for pharmaceuticals in Soil, Lettuce, and Earthworms
27/04/2024 -
The presence of human and veterinary pharmaceuticals (PhACs) in the environment poses potential risks. To comprehensively assess these risks, robust multiresidual analytical methods are essential...
Pharmacological Significance of Boraginaceae with Special Insights into Shikonin and Its Potential in the Food Industry
27/04/2024 -
Shikonin is a naphthoquinone pigment present in the hairy roots of the plant species from the Boraginaceae family. The compound has been well investigated for its highly efficient medicinal,...
Synthesis of MPEG-b-PLLA Diblock Copolymers and Their Crystallization Performance with PDLA and PLLA Composite Films
29/04/2024 -
Methoxy poly(ethylene glycol)-block-poly(L-lactide) (MPEG-b-PLLA) has a wide range of applications in pharmaceuticals and biology, and its structure and morphology have been thoroughly studied. In...
Impact of Drying Method and Solvent Extraction on Ethiopian Verbascum sinaiticum (Qetetina) Leaves: Metabolite Profiling and Evaluation of Antioxidant Capacity
29/04/2024 -
The aim of this study was to evaluate the effects of different drying methods on bioactive compounds and to analyze their composition in Verbascum sinaiticum (V. sinaiticum) leaf extracts using...
Recent development of photoresponsive materials toward 3D printing: From materials to application
22/04/2024 -
The rapid development of 3D printing has achieved considerable progress in architecture innovation, optical advancements, energy systems, dental care, pharmaceutical delivery, and personalized...
