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Loureirin B inhibits Cervical Cancer Development by Blocking PI3K/AKT Signaling Pathway: Network Pharmacology Analysis and Experimental Validation
- Abstract Loureirin B (LB) is an iconic component of Chinese dragonâ??s blood that presents anti-cancer effects in gastric cancer and liver cancer. Although LB has shown benefits...
Assessing the Role of Detergents in Pond Ecosystem
- Abstract Detergents are used as a part of our daily life routine. Though they are widely used but their active ingredients which are highly toxic and persist in the environment...
Advanced three?dimensional in vitro liver models to study the activity of anticancer drugs
19/06/2024 - Graphical Abstract and Lay Summary  3D liver aggregates formed with three main liver cell types such a hepatocytes, hepatic stellate cells and hepatic sinusoidal endothelial cells psented in vivo...
The medicinal chemistry of piperazines: A review
18/06/2024 - Medicinal chemistry of piperazine and its derivatives.The versatile basic structure of piperazine allows for the development and production of newer bioactive molecules that can be used to treat a...
One?Pot Hydrothermal?Derived rGO/MXene/Sulfur Composite Aerogels as Free?Standing Cathodes in Lithium?Sulfur Batteries
19/06/2024 - The confinement and high utilization of sulfur in the cathodes is critical for improved cycling performance of lithium?sulfur batteries. In this case one?pot hydrothermal strategy is developed to...
Interstate Air Pollution Governance in the United States: Exploring Clean Air Act Section 126
- Air pollution is arguably the most pressing human health concern today, accounting for approximately 7–9 million premature deaths worldwide. In the United States, more than 40% of early deaths...
Advantages and drawbacks of life cycle assessment application to the pharmaceuticals: a short critical literature review
19/06/2024 - Pharmaceuticals are among the most challenging products to assess by life cycle assessment (LCA). The main drawback highlighted by LCA practitioners is the lack of inventory data, both regarding...
Hydrodynamics and water quality of a highly anthropized wetland: the case study of the Massaciuccoli basin (Tuscany, Italy)
18/06/2024 - Owing to increasing anthropogenic impacts, wetlands have suffered a serious environmental decline in recent decades. The sustainable management of these natural resources is fundamental to...
Anomaly Detection in Materials Digital Twins with Multiscale ICME for Additive Manufacturing
19/06/2024 - Abstract Detecting anomaly in fatigue and fracture experimental materials science is an interesting yet challenging topic. The reasons are threefold. First, the anomalous...
Processing improvement of response and stability of strain sensor based on CNT?bioplastic composite for estimation of elbow angles
19/06/2024 - d?limonene sensing.AbstractThis paper introduces a novel wearable flexible gas sensor designed specifically for the detection of d?limonene. The sensor utilizes materials recognized for their high...
Enhancing antibacterial characteristics of paper through silver-exchanged zeolite coating for packaging paper
18/06/2024 - AbstractThis study aims to create paper packaging by developing paper coated with silver-exchanged zeolite that provides the necessary antibacterial properties. Various coating solutions...
Tuning Spatially Resolved Shape Memory Effects of Stimuli?Responsive Macroporous Photonic Crystals
16/06/2024 - Stimuli?responsive photonic crystals with patterned microstructures are of great interest in developing reconfigurable nanooptical devices. Leveraging unconventional all?room?temperature shape memory...
The Toughness of Interlocking Metasurfaces
13/06/2024 - Interlocking metasurfaces (ILMs) are surface feature arrays that enable the joining of two bodies. In this study, the toughening behavior of ILMs, where the process zone size and associated...
Unveiling Enhanced Properties via Microstructural Evolution in Stir?Cast Al6061 Composite Reinforced with AlCrFeNiTi High?Entropy Alloy Particles.
13/06/2024 - Viability of reinforcing the Al 6061 matrix using AlCrFeNi and AlCrFeNiTi High Entropy alloy (HEA) particles were investigated. BCC, A2 and TiC phase were observed in both alloys after 12 hours of...
Innovative Formulation Platform: Paving the Way for Superior Protein Therapeutics with Enhanced Efficacy and Broadened Applications
16/06/2024 - Protein therapeutics hold great promise for treating various diseases, yet their delivery remains challenging. This review introduces “Pcapsulation,” a protein formulation technology....
LCMS Based Untargeted Metabolic Profiling Revealed a Strong Association of Nanoselenium Treated Sesame (Sesamum indicum) Seed Bioactive Compounds as Novel Potential Disease Targets- A Nano-bioinformatics Approach
- Abstract The convergence of nanotechnology with bioinformatics and the study of plant secondary metabolites hold remarkable potential for transformative scientific breakthroughs....
Commitment of human mesenchymal stromal cells towards ACL fibroblast differentiation upon rAAV?mediated FGF?2 and TGF?? overexpression using pNaSS?grafted PCL films
14/06/2024 - An innovative strategy combining gene therapy and tissue engineering procedures was elaborated in this study to enhance anterior cruciate ligament (ACL) repair. Biomaterial?guided rAAV?mediated FGF?2...
Ruthenium(II) Polypyridyl Complexes with Benzoxazole Derivatives and Non?Innocent Ligands as Effective Antioxidants in Human Neuroblasts
14/06/2024 - The combination of benzoxazole derivatives with non?innocent ligands in the same ruthenium(II) polypyridyl complex is a suitable strategy to design new pharmacological tools with ROS?scavenging...
Total Synthesis of (15R)? and (15S)?Prostaglandin A2
14/06/2024 - From both pharmaceutical and structural perspectives, the large family of prostaglandins represent a truly remarkable class of natural products. Prostaglandin A2 is a tissue hormone naturally found...
Optimizing Green Synthesis of Hydrotalcite – Silver Nanoparticles using Syzygium Nervosum based Reducing Agent
14/06/2024 - This work aimed to assess the effect of Syzygium nervosum leaf extract as a reducing agent for green synthesis of AgNPs on HT through an optimizing process using response surface methodology and the...
Emotionality in Transboundary Water: A Case Study of Helmand River
- While a substantial body of literature perceives rationality as the only path for negotiations over the use of the transboundary shared watercourse, recent scholarship has unveiled the role of...